Spatio-temporal alterations in resting-state co-activation patterns in a rat model of sporadic Alzheimer’s disease
AUTHORS: Diao Y, Gruetter R, Jelescu I
ISMRM & SMRT Annual Meeting, : , Online, May 2021
Impaired brain glucose consumption is a possible trigger of Alzheimer’s disease (AD). Previous work revealed affected brain structure and function by insulin resistance in terms of altered static functional connectivity (FC) in an intracerebroventricular-streptozotocin (icv-STZ) rat model of AD. Here, we used the co-activation patterns (CAP) method, a dynamic FC approach, to assess differences between icv-STZ rats and healthy controls. STZ rats displayed early higher predominance of states involving brain regions shown as hyperconnected by the static FC analysis. Longitudinally, specific brain states declined in the STZ rats only.