AUTHORS: Winkel D. J., Stoiber L., Xiong T., Stuber M., Hays A. G., Plöckinger U., Doeblin P., Stehning C., Kelle S.

American Journal of Cardiovascular Disease, : , 15 April 2023

ABSTRACT

Aims

No data is available about the significance of cardiovascular magnetic resonance (CMR) derived vascular distensibility (VD) and vessel wall ratio (VWR) for risk stratification in patients with type 2 diabetes mellitus (T2DM). Therefore, this study aimed to investigate the effects of T2DM on VD and VWR using CMR in both central and peripheral territories.

Methods

Thirty-one T2DM-patients and nine controls underwent CMR. Angulation of the aorta, the common carotid, and the coronary arteries was performed to obtain cross-sectional vessel areas.

Results

In T2DM the Carotid-VWR and the Aortic-VWR correlated significantly. Mean values of Carotid-VWR and Aortic-VWR were significantly higher in T2DM than in controls. Coronary-VD was significantly lower in T2DM than in controls. No significant difference in Carotid-VD or Aortic-VD in T2DM vs. controls, respectively, could be observed. In a subgroup of thirteen T2DM patients with coronary artery disease (CAD), Coronary-VD was significantly lower and Aortic-VWR was significantly higher compared to T2DM patients without CAD.

Conclusion

CMR allows a simultaneous evaluation of the structure and function of three important vascular territories to detect vascular remodeling in T2DM.

Keywords

CMR; Coronary artery disease; aorta distensibility; cardiac MRI; caritid; cross-sectional studies; diabetes mellitus; magnetic resonance imaging; type 2; vascular remodeling.

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