AUTHORS: Dwir I, Khadimallah L, Xin L, Rahman M, Du F, Öngür D, Do K Q

International Journal of Neuropsychopharmacology, 13: 1075564, March 2023


Redox biology and immune signaling play major roles in the body, including in brain function. A rapidly growing literature also suggests that redox and immune abnormalities are implicated in neuropsychiatric conditions such as schizophrenia, bipolar disorder, autism, and epilepsy. In this article we review this literature, its implications for the pathophysiology of schizophrenia, and the potential for development of novel treatment interventions targeting redox and immune signaling. Redox biology and immune signaling in the brain are complex and not fully understood; in addition, there are discrepancies in the literature, especially in patient-oriented studies. Nevertheless, it is clear that abnormalities arise in schizophrenia from an interaction between genetic and environmental factors during sensitive periods of brain development and these abnormalities disrupt local circuits and long-range connectivity. Interventions that correct these abnormalities may be effective in normalizing brain function in psychotic disorders, especially in early phases of illness.