AUTHORS: Rahmanzadeh R, Lu PJ, Barakovic M, Weigel M, Gaetano L, Galbusera R, Nguyen TD, La Rosa F, Reich DS, Sati P, Wang Y, Bach Cuadra M, Radue EW, Kuhle J, Kappos L, Magon S, Granziera C

Proceedings of the 29th ISMRM & SMRT Annual Meeting, : , Online, May 2021

ABSTRACT

The differential sensitivity of myelin-sensitive  advanced MRIs (aMRIs) to the pathology in various brain lesions and regions in multiple sclerosis (MS) is currently debated. This study aimed to address this issue using myelin water  fraction maps (MWF), quantitative susceptibility mapping (QSM) and T1 relaxometry (qT1). Our results show that (i) qT1 is the most sensitive in differentiating white matter and cortical MS lesions from normal-appearing tissue (ii) QSM is best differentiating lesions with various extent of damage (lesions with vs without paramagnetic rim & periventricular vs juxta-cortical lesions) and (iii) MWF outperforms the other aMRI methods in identifying occult normal appearing pathology.

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