Protective role of Creatine in chronic hepatic encephalopathy developing brain: in vivolongitudinal H and P-MRS study
AUTHORS: Simicic D, Pierzchala K, Braissant O, Mitrea SO, Sessa D, McLin V, Cudalbu C
ISMRM & SMRT Annual Meeting, : , Online, May 2021
Type-C hepatic encephalopathy (CHE) is a complication of chronic liver disease (CLD). It is known that children are more affected by CLD than adult patients. Bile duct ligated rat (BDL) is a model of CLD-induced CHE. It was shown that rats having acquired CLD as pups display more profound neurometabolic disturbances than adults.
Cr-treatment showed a positive effect in youngP21 BDL-rats resulting in less pronounced metabolic changes. Our aim was to test whether Cr-supplementation dampens the changes observed in CHE in a longitudinal model of CLD acquired in early childhood-P15 and if these changes are similar to those in P21-rats.