In vivo mapping of human locus coeruleus functional connectivity at 7T: a feasibility study
AUTHORS: Pievani M, Jelescu I, Jorge J, Reynaud O, Ribaldi F, Garibotto V, Frisoni GB, Jovicich J
ISMRM & SMRT Annual Meeting, : , Online, May 2021
The locus coeruleus (LC) is a brainstem nucleus whose functional disruption may be an early signature of Alzheimer’s disease. Potentially due to its small size, mixed results exist about its functional connectivity to core memory, attention and salience networks. This limits a baseline definition for patient studies. Here we use high-resolution high-field resting-state fMRI to investigate the pattern of LC connectivity in healthy young subjects. Preliminary findings show positive correlations with the cerebellum and the frontal cortex. The default mode and frontoparietal networks, but not the salience network, show FC with the brainstem. Data acquisition is ongoing.