Fast high-resolution metabolite mapping on a preclinical 14.1 T scanner using H-FID-MRSI
AUTHORS: Simicic D, Brayan Alves B, Mosso JJ, Phong Lê TP, van Heeswijk RB, Starcukova J, Klauser A, Strasser B, Wolfgang Bogner W, Cudalbu C
Proceedings of the Joint Annual Meeting ISMRM-ESMRMB 2022, 2p: , September 2022
1 H-MRSI enables a simultaneous acquisition of MR-spectra from multiple spatial locations inside the brain. While 1 H-MRSI is increasingly used in the human brain, its implementation in preclinical setting is limited because of the smaller size of rodent brain. At UHF for humans, 1 H-FID-MRSI acquisitions are increasingly used (T 2 and J-evolution minimization, increased SNR). We present the first implementation of fast 1 H-FID-MRSI in the rat brain at 14.1 T and exploit its potential for an increased brain coverage, reliable and accurate quantification results and metabolic maps. Our results set the grounds for a wider application of 1 H-FID-MRSI in the preclinical setting.