3D whole brain mapping of creatine kinase metabolic rate using 31P-MR fingerprinting

AUTHORS: Widmaier M., Kaiser A., Xiao Y., Huang Z., Jiang Y., Lim S., Wenz D., Xin L.

ISMRM & SMRT Annual Meeting & Exhibition, : , Singapore, May 2024

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ABSTRACT

Motivation

Using ³¹P MRS combined with magnetization transfer (MT) experiments including saturation transfer or inversion transfer to assess chemical exchange rate of creatine kinase (k_CK) in the human brain are time-consuming and limited to 1D-acquisitions.

Goal

Acquiring a 3D whole brain k_CK map.

Approach

In this abstract, we introduce an advanced, fast 3D-³¹P-MRF sequence for the human brain at 7T.

Results

The novel 3D-³¹P-MRF approach is feasible for whole brain mapping of k_CK, enabling the investigation of region-specific energy metabolism under various pathological conditions.

Impact

Using the novel 3D-³¹P-MR Fingerprinting approach for whole brain mapping of k_CK enables us to investigate region-specific energy metabolism under various pathological conditions and may enhance our understanding of the underlying molecular and metabolic processes.

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BibTex

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Module: MRI