AUTHORS: Liverani MC, Freitas L, Siredi V, Mikneviciute G, Martuzzi R, Meskaldji DE, Borradori Tolsa C, Leuchter R, Schnider A, Van De Ville D, Huppi P
Journal of Neurosurgery, 10(4): , April 2020
ABSTRACT
Introduction
Orbitofrontal reality filtering (ORFi) is a memory mechanism that distinguishes whether a thought is relevant to present reality or not. In adults, it is mediated by the orbitofrontal cortex (OFC). This region is still not fully developed in preteenagers, but ORFi is already active from age 7. Here, we probe the neural correlates of ORFi in early adolescents, hypothesizing that OFC mediates the sense of reality in this population.
Methods
Functional magnetic resonance images (fMRI) were acquired in 22 early adolescents during a task composed of two runs: run 1 measuring recognition capacity; run 2 measuring ORFi; each containing two types of images (conditions): distractors (D: images seen for the first time in the current run) and targets (T: images seen for the second time in the current run). Group region of interest (ROI) analysis was performed in a flexible factorial design with two factors (run and condition) using SPM12.
Results
We found significant main effects for the experimental run and condition. The bilateral OFC activation was higher during ORFi than during the first run. Additionally, the OFC was more active while processing distractors than targets.
Conclusion
These results confirm, for the first time, the role of OFC in reality filtering in early adolescents.
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Module: SP
