AUTHORS: Lai SF, Chien CC, Chen WC, Chen HH, Chen YY, Wang CL, Hwu Y, Yange CS, Chen CY, Liang KS, Petibois C, Tanij HR, Tok ES, Margaritondo G

Biotechnology Advances, 31(3): 362-368, May 2013

ABSTRACT

An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with MUA (11-mercaptoundecanoid acid), are very small (1.4 nm diameter); the above two properties are not present for even slightly larger sizes. The small MUA-AuNPs are non-cytotoxic (except for very high concentrations) and do not interfere with cancer cell proliferation. Multimodality imaging using visible light fluorescence and X-ray microscopy is demonstrated by tracing the nanoparticle-loaded tumor cells.

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