CIBM PET HUG-UNIGE SECTION

Molecular Imaging

Section Head: Prof. Martin Walter (HUG-UNIGE)

Brief introduction to the Section coming soon 

RESEARCH TOPICS

Preclinical Models

Description: In cancer research, preclinical models reflecting human biology are crucial for the development and validation of new therapeutics and imaging methods. However, common models used in research poorly reproduce the clinical reality of the micro-environment impacting tumour growth and response to treatment. We aim to develop new reliable and innovative in vitro (spheroids), in ovo (CAM) and in vivo (orthotopic xenograft) preclinical models and implement them into different research topics. Resorting to these powerful biological tools strongly improve the translational power of the preclinical research and help to reduce and replace animal experimentation with alternatives.

Investigator: Martin Walter (UNIGE), Olivia Bejuy (UNIGE), Stéphane Germain (UNIGE)

Collaborator: Didier Colin (UNIGE)

Cancer Theranostic

Description: Cancer cells express many key proteins differentiating them form healthy cells. These proteins are targeted by modern medicine for imaging and therapy as they allow acquisition of diagnostic images and delivery of therapeutic doses of radiation to the patient. However, some tumours mainly harboured by patients with advanced disease, loose the expression of these key proteins making imaging and treatment impossible. Our research aims to reestablish or upregulate the expression of these proteins. To ensure a rapid translation of our preclinical research, we mainly focus on screening drugs that are already clinically validated. We identify potent drugs by in vitro screening and validate our findings in ovo and in vivo by preclinical PET/CT imaging.

Investigators: Martin Walter (UNIGE), Vincent Taelman (UNIGE), Olivia Bejuy (UNIGE), Stéphane Germain (UNIGE)

Collaborator: Didier Colin (UNIGE)

Genome Imaging

Description: The Imageable Genome project of the HUG Service of Nuclear Medicine and Molecular Imaging strives to improve the accessibility of the human genome by facilitating non-invasive characterization of gene expression data in the whole body by PET imaging. The overarching aim of this project is to gain insight into the dynamics of gene expression in living humans, and to translate this information to improved patient care in various disease states.

Investigators: Martin Walter (UNIGE), Vincent Taelman (UNIGE)

Collaborators: Coming soon…