Description: In cancer research, preclinical models reflecting human biology are crucial for the development and validation of new therapeutics and imaging methods. However, common models used in research poorly reproduce the clinical reality of the micro-environment impacting tumour growth and response to treatment. We aim to develop new reliable and innovative in vitro (spheroids), in ovo (CAM) and in vivo (orthotopic xenograft) preclinical models and implement them into different research topics. Resorting to these powerful biological tools strongly improve the translational power of the preclinical research and help to reduce and replace animal experimentation with alternatives.
Investigator: Martin Walter (UNIGE), Olivia Bejuy (UNIGE), Stéphane Germain (UNIGE)
Collaborator: Didier Colin (UNIGE)