Breakfast & Science Seminar 26

We are pleased to invite you to the CIBM Breakfast & Science Seminar #26 – 2022 Summer Edition which will be hybrid – both virtual and on-site:

Date and time: Tuesday June 28th, 2021 – 9:00 to 10:30 CEST

Location: Virtual on Zoom and on-site CIBM Seminar Room, EPFL campus, 1015 Lausanne.


09:00 – 09:30  Deep learning methods for fetal brain MRI tissue segmentation

Priscille Guerrier de Dumast,

Abstract: The quantitative assessment of the developing human brain in utero is crucial to fully understand neurodevelopment. T2-weighted magnetic resonance imaging offers a good contrast between brain tissues, hence allowing to assess the brain growth and detect abnormalities in utero. In the clinical context, fetal brain MRI is performed with fast, 2D orthogonal series in order to minimize the effect of unpredictable fetal motion but results in low out-of-plane spatial resolution and significant partial volume effect. To combine these multiple series, advanced imaging techniques based on super-resolution (SR) algorithms allow the reconstruction of 3D high-resolution motion-free isotropic volumes. Such high-resolution volume opens up to the possibility of advanced quantitative analysis of improved accuracy. Accurate MR image segmentation, and more importantly a topologically correct delineation of the structure, is a key baseline to perform further morphometric and volumetric analysis of brain development. Nevertheless, the development of automatic machine learning based methods is hampered by the scarcity of the data and their multiple sources of variability. In this talk, I will discuss my work on the introduction of a topological constraint in the segmentation of the developing fetal cortical plate.

PhD Supervisors: Dr. Meritxell Bach Cuadra (CIBM SP CHUV-UNIL)

09:30 – 10:00  Fast in vivo assay of creatine kinase in human brain by 31P magnetic resonance fingerprinting
Mark Widmaier,

Abstract: 31P MRS is a powerful tool for studying brain energy metabolism, however, it remains a challenging task. Especially, relaxometry and chemical exchange rates acquisitions, suffer from the inherent low sensitivity and long acquisition times. We introduce MT- 31P magnetic resonance fingerprinting, using a SAR efficient magnetization transfer (MT) approach. We extended the magnet resonance fingerprinting (MRF) framework to overcome obstacles of in vivo human brain 31P measurements. The result is an efficient way to measure relaxation parameters and the creatine kinase rate kCK, enabling ultra-fast kCK measurement in up to 2:15 min scan time. This talk will give a short journey into the challenges and possibilities of 31P-MRF.

CO-Supervisor: Dr. Lijing Xin (CIBM MRI EPFL)  & Prof. Rolf Gruetter (EPFL)

10:00-10:30  CIBM News and Updates

Please register by Monday June 27, 2022, 12:00

To join us on Zoom, please register at the following link:–prjsiGdLCnbzjiKSMTeIRJGe0Nwpo

To attend on site, please register here, as places are limited:

After registering, you will receive a confirmation email containing information about joining the meeting.

We look forward to seeing you soon.


28 Jun 2022


9:00 am - 10:30 am



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