Breakfast & Science Seminar 17
We are pleased to invite you to the seventeenth CIBM Breakfast & Science Seminar which is part of the three B&S 2021 Summer Edition featuring PhD students affiliated to CIBM founding partner institutions to present their research work. :
Date and time: Tuesday August 31st, 2021 – 9:00 to 10:30 CEST
Location: Online seminar
Program
09:00 – 09:30 New insights into brain energy metabolism in type C hepatic encephalopathy: a dual 18F-FDG PET and 9.4T 1H MRS preclinical study
Jessie Mosso,
LIFMET, EPFL
Abstract: Type C hepatic encephalopathy (HE) is a severe neuropsychiatric decline occurring as a consequence of chronic liver disease and which drastically affects patients’ lives. Energy metabolism alterations have been suggested in HE, but in vivo studies remain sparse and have reported conflicting results. Here, we propose an atlas-based coregistration of preclinical 18F-FDG PET with localized 1H-MR spectroscopy, providing regional and quantitative information on both brain glucose uptake and neurometabolic profiles. In a rat model of type C HE, a 2-fold lower brain glucose uptake, concomitant with an increase in brain glutamine and a decrease in the main osmolytes was observed in the hippocampus and in the cerebellum. These findings are an important step towards new insights into brain energy metabolism in the pathophysiology of HE.
Co-Supervisors: Dr. Cristina Cudalbu (CIBM MRI EPFL) & Prof. Rolf Gruetter (EPFL)
09:30 – 10:00 Towards super-resolution reconstruction of fetal brain MRI
Hamza Kebiri,
Medical Image Analysis Lab, UNIL
Abstract: Fetal Diffusion Magnetic Resonance Imaging (dMRI) is greatly limited in Signal-to-Noise ratio and spatial resolution. Due to the uncontrollable fetal motion, echo planar imaging acquisitions often result in highly degraded images, hence the ability to depict precise diffusion MR properties remains unknown. The first part of the talk will cover the assessment of the effect of scanning settings on diffusion quantities in a crossing phantom specifically designed to mimic typical values in the fetal brain. Quantitative evaluation was carried out on the number of diffusion gradient directions, different orthogonal acquisitions, and enhanced 4D volumes from super-resolution reconstruction of multiple series. In the second part of this talk, I will present preliminary results on an unsupervised learning method using a variational autoencoder to perform through-plane super-resolution on both phantom and in vivo fetal data.
Supervisor: Dr. Meritxell Bach Cuadra (CIBM SP CHUV-UNIL)
10:00-10:30 CIBM News and Updates
Please register by Monday August 30, 2021, 12:00 at the following link: https://epfl.zoom.us/meeting/register/tZEpfuuhqTsjHdBy06DqzBLB-UW7N69ixjTZ
After registering, you will receive a confirmation email containing information about joining the meeting.
We look forward to seeing you soon.
