The 2021 Summer Edition of the CIBM Breakfast and Science Seminar series featured PhD students affiliated to CIBM founding partner institutions to present their research work.

MP2RAGE image synthesis for improved tissue and white matter and cortical lesion segmentation in multiple sclerosis patients

Francesco La Rosa,

Abstract: Specialized MRI sequences such as the magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) show a higher brain tissue and lesion contrast in multiple sclerosis (MS) patients, including advanced biomarkers such as cortical lesions. However, these sequences are in most cases not acquired in the clinical practice yet and remain used in research settings. In this talk, I will first briefly introduce a MS white matter and cortical lesion segmentation framework based on FLAIR and MP2RAGE at 3T. Secondly, I will present an automated method, based on a generative adversarial network, to translate the conventional magnetization-prepared rapid gradient-echo imaging (MPRAGE) to synthetic MP2RAGE. Combining these two methods (for segmentation and image synthesis) we show that the synthetic images improve both the automated tissue and lesion segmentation in MS patients.

PhD Supervisors: Prof. Jean-Philippe Thiran (CIBM SP CHUV-EPFL) & Dr. Meritxell Bach Cuadra (CIBM SP CHUV-UNIL)

RyanImproving HIFU with a New Perfluorocarbon Adjuvant

Ryan Hawley Holman,
Image-Guided Interventions Laboratory, Department of Radiology and Medical Informatics, HUG

Abstract: :
The burgeoning technique of focused ultrasound provides alternative non-invasive surgical treatment options for a variety of conditions. This talk will discuss the application of a new type of fluorosurfactant perfluorocarbon emulsion that might be applied intravenously to improve the therapy. The technique is in the preclinical stage and studies continue for clinical translation. The talk will describe the background information, the main study results thus far, potential future clinical applications, and the route to the first feasibility study.

PhD Supervisor: Prof. Rares Salomir, HUG

The monthly meet-up seminar series is a great environment to ask questions or to share insights on challenges and solutions. It’s also a good way to broaden and enrich professional networks.

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