Multimodal Magnetic Resonance Imaging Depicts Widespread and Subregion Specific Anomalies in the Thalamus of Early-Psychosis and Chronic Schizophrenia Patients

Name: Breakfast & Science Seminar 32
Start: 2023-03-28
End: 2023-03-28
Location: CIBM EPFL Seminar room

AUTHORS: Alemán-Gómez Y, Baumgartner T, Klauser P, Cleusix M, Jenni R, Hagmann P, Conus P, Do QK, Cuadra MB, Baumann PS, Steullet P

Schizophrenia Bulletin, 49(1): 196-207, September 2022

ABSTRACT

Compared to age-matched controls, the thalamus of EP patients displays previously unreported widespread microstructural alterations (VF_INTRA decrease, TD_EXTRA increase) that are associated with similar alterations in the whole brain white matter, suggesting altered integrity of white matter fiber tracts in the thalamus. In both patient groups, we also observed more localized and heterogenous changes (either GMC decrease, MD_EXTRA increase, or DIFF_INTRA decrease) in mediodorsal, posterior, and ventral anterior parts of the thalamus in both patient groups, suggesting that the nature of the alterations varies across subregions. GMC and DIFF_INTRA in the whole thalamus correlate with global functioning, while DIFF_INTRA in the subregion encompassing the medial pulvinar is significantly associated with negative symptoms in SCHZ.

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