BEGIN:VCALENDAR
VERSION:2.0
METHOD:PUBLISH
CALSCALE:GREGORIAN
PRODID:-//WordPress - MECv7.34.2//EN
X-ORIGINAL-URL:https://cibm.ch/
X-WR-CALNAME:CIBM  |  Center for Biomedical Imaging
X-WR-CALDESC:
X-WR-TIMEZONE:Europe/Zurich
BEGIN:VTIMEZONE
TZID:Europe/Zurich
X-LIC-LOCATION:Europe/Zurich
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T030000
RRULE:FREQ=YEARLY;BYMONTH=03;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20261025T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=4SU
END:STANDARD
END:VTIMEZONE
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-PUBLISHED-TTL:PT1H
X-MS-OLK-FORCEINSPECTOROPEN:TRUE
BEGIN:VEVENT
CLASS:PUBLIC
UID:MEC-6b3a8f76ca145c9db850d0d318d381a6@cibm.ch
DTSTART;TZID=Europe/Zurich:20260824T100000
DTEND;TZID=Europe/Zurich:20260824T113000
DTSTAMP:20260707T093628Z
CREATED:20260707
LAST-MODIFIED:20260707
PRIORITY:5
SEQUENCE:1
TRANSP:OPAQUE
SUMMARY:Visitors Talk: Fei Du, Mclean hospital – Harvard Medical School
DESCRIPTION:Hosted by Lijing Xin ( https://cibm.ch/community/lijing-xin/ ), Research Staff Scientist CIBM MRI EPFL Section, we are pleased  to invite you to attend the CIBM Visitors Talk on August 24th at 10:00 CEST by Fei Du from the McLean Imaging Center, Martinos Center for Biomedical Imaging, Harvard Medical School who will be sharing on “ Unravelling Molecular Mechanisms Underlying Disrupted Brain Circuits in Neuropsychiatric Disorders: Advanced Neuroimaging and Biomarker Discovery”.\nDate and time: Monday, August 24th, 2026 – 10:00 CEST\nLocation:  CIBM seminar room, EPFL, Lausanne & online\n																														\nFei Du\nMclean hospital – Harvard Medical School\nAbout the speaker \nDr. Fei Du is a neuroimaging physicist, the director of Laboratory for High-Field Imaging and Translational Neuroscience at McLean Hospital, and an Associate Professor in Harvard Medical School. He earned his Ph.D. in NMR quantum physics from the Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, followed by postdoctoral training at CMRR, University of Minnesota, before joining McLean Hospital. His research focuses on integrating MRI/MRS technique developments with translational neuroimaging, aiming to outline biological abnormalities’ trajectories and identify treatment-engaged targets and biomarkers for disease progression and treatment in neuropsychiatric disorders.\nTALK: Unravelling Molecular Mechanisms Underlying Disrupted Brain Circuits in Neuropsychiatric Disorders: Advanced Neuroimaging and Biomarker Discovery\nAbstract\nImpaired functional connectivity is a hallmark of various neuropsychiatric disorders, yet the molecular mechanisms driving these disruptions remain elusive and few in vivo biomarkers are available to guide clinical interventions. Emerging evidence suggests that a central “immuno-oxidative” pathway, involving NMDA receptor hypofunction, redox dysregulation, neuroinflammation and mitochondrial dysfunction, plays a pivotal role and contributes to disrupted brain circuits in neuropsychiatric disorders. In this presentation, I will introduce novel approaches for quantifying in vivo levels of glutamate/GABA, glutathione (GSH), and redox ratio of NAD+ and NADH, alongside measuring creatine kinase/ATPase activities (mitochondrial function) in the same experimental session. Through the integration of the multimodal neuroimaging with assessments of brain structural and functional connectivity, we have identified associations among these measures, but they are compromised in neuropsychiatric patients. Our findings indicate that reduced energy metabolic rates with diminished neurotransmissions might disrupt the long distance and large-scale neuronal communications—thereby leading to brain disorders and suggest that the metabolism-neural synchrony pathway could be a new potential treatment target for various neuropsychiatric diseases including neuropsychiatric disorders. The interventions of NAD+ supplementation and ketogenic therapy as well as diseases progression also will be discussed. These advances might provide the biomarkers for documenting and quantifying the neurobiological abnormalities’ trajectories and effects of interventions using brain imaging approaches.\nSeminar Chair\n																														\nLijing Xin\nResearch Staff Scientist, CIBM MRI EPFL Section\nClick here to know more about Lijing Xin ( https://cibm.ch/community/lijing-xin/ )\nJOIN US ON SITE!\nYou are welcome to join us on site at the CIBM seminar room, EPFL, Lausanne. The event is for free and registration is not required.\nOR REMOTELY\nTo join us remotely please,  register at the following Zoom link:https://epfl.zoom.us/meeting/register/J9fJmYSQStOHtZMlxhTgaw \nZoom Code: 653 9574 7315\nWe look forward to seeing you there!\n
URL:https://cibm.ch/event/visitors-talk-fei-du-mclean-hospital-harvard-medical-school/
CATEGORIES:Talk,Visitor's talk
LOCATION:CIBM seminar room, EPFL, Lausanne & online
END:VEVENT
END:VCALENDAR