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SUMMARY:Visitors Talk: Qunxiang Ong, A*STAR, Singapore
DESCRIPTION:Hosted by Andrea Capozzi, EPFL, we are pleased  to invite you to attend the CIBM Visitors Talk on October 13th at 11:00 CET by Qunxiang Ong from the A*STAR, Singapore who will be sharing on “Hyperpolarizable Probe Development and the Biological Applications”.\n					\n									REGISTER HERE\n					\n																														\nQunxiang Ong\nA*STAR, Singapore\nAbstract\nMetabolic imaging has entered an exciting era with the advent of hyperpolarized magnetic resonance spectroscopy (MRS), which amplifies nuclear spin polarization to enhance signal sensitivity by more than 10,000-fold. This breakthrough enables real-time visualization of biochemical reactions in living systems with unprecedented temporal and spatial resolution. In this talk, I will discuss the design and development of novel hyperpolarizable probes, focusing on molecular engineering strategies that extend beyond conventional substrates like [1-13C]pyruvate. I will highlight recent advances from our lab, including a new class of 13C-labeled amino acid probes capable of tracking transamination flux and redox states in cancer and liver disease. Beyond probe chemistry, I will discuss the roadmap where we work on emerging biological applications that taps on hyperpolarized imaging to provide mechanistic insight—ranging from tumor metabolism to neurochemical dynamics and therapeutic response assessment. Together, these innovations chart a path toward more personalized and mechanism-driven diagnostics, bridging molecular biology and clinical imaging through hyperpolarization technology.\nAbout the speaker \nDr. Qunxiang Ong is a Senior Scientist at the Institute of Molecular & Cell Biology (IMCB), part of A*STAR in Singapore, where he leads the MRI platform and probe-development efforts. He works at the crossroads of chemistry, molecular imaging, and biological signaling, pushing the boundaries of what molecular probes and imaging modalities can reveal in living systems.He obtained his PhD in Organic Chemistry / Chemical Biology from Stanford University in 2018, where his work involved advanced optogenetic tool development (in the lab of Prof. Bianxiao Cui). Over the course of his career, Dr. Ong has published on the development of optogenetic probes, post-translational signaling (e.g. studies of O-GlcNAc dynamics), metabolic sensing, and imaging tool innovation.Today, he will share his latest advances and perspectives in hyperpolarizable probe development and their biological applications — a topic that integrates his expertise in chemical tool design, imaging physics, and biological insight.\n \nDate and time\nMonday, October 13th at 11h00 CET\nLocation\nCIBM seminar room, EPFL, Lausanne & online\nSeminar Chair\n\n \nAndrea Capozzi\nPolarize\n \nJOIN US!\nIf attending on-site, the event is for free but registration is mandatory. REGISTER HERE.\nTo join us on Zoom:https://epfl.zoom.us/meeting/register/chD8de9LQ1u0TNDu5ZezgQ  (Meeting ID: 613 3840 5793)\nWe look forward to seeing you there!\n					\n									REGISTER HERE\n					\n
URL:https://cibm.ch/event/visitors-talk-qunxiang-ong-astar-singapore/
CATEGORIES:Talk,Visitor's talk
LOCATION:CIBM seminar room, EPFL, Lausanne & online
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